Lack of Association between LCT_rs140433552*CA>del Indel Polymorphism and Lactose Intolerance in a Southern Brazilian Population

• Main Authors: Luana Caroline Oliveira, Andrey Lucas Dias Barros, Angelica Beate Winter Boldt, Gabriel Adelman Cipolla
• Format: Article
• Language: English
• Published: Karger Publishers 2020-07-01
• Series: Lifestyle Genomics
• Subjects: rs140433552*ca>del; indel; 3′ untranslated region; lct; haplotypes; lactose intolerance; genetic susceptibility
• Online Access: https://www.karger.com/Article/FullText/508509
• ISSN: 2504-3161; 2504-3188

Background/Aims: Polymorphisms in the enhancer of the lactase gene (LCT) are strongly associated with lactase persistence, but not always predictive of the phenotype. We investigated a possible association between the regulatory rs140433552*CA>del variant of LCT and lactose intolerance (LI). Methods: We genotyped 122 individuals for rs140433552 and rs4988235 (–13910*C>T). Results: Associations of rs140433552*CA>del with LI depend on –13910*C>T. Homozygous individuals for the C-CA haplotype, as well as C-CA+/C individuals, seem more likely to manifest LI (OR 3.33 [95% CI 1.32–8.35], p = 0.011, and OR 3.93 [95% CI 1.61–9.61], p = 0.003, respectively), while homozygous individuals for the T-CA haplotype seem more likely to be lactose tolerant (OR 0.04 [95% CI 0.002–0.70], p = 8 × 10–4). Conclusions: rs140433552*CA>del is not independently associated with LI.