Inhibition of retinoic acid receptor α phosphorylation represses the progression of triple-negative breast cancer via transactivating miR-3074-5p to target DHRS3

Inhibition of retinoic acid receptor α phosphorylation represses the progression of triple-negative breast cancer via transactivating miR-3074-5p to target DHRS3

Abstract Background Retinoids are promising agents in the treatment of different types of neoplasia including estrogen receptor-positive breast cancers, whereas refractoriness/low sensitivity is observed in triple-negative breast cancer (TNBC) subtype. However, the reason for these diverse retinoid-...

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Bibliographic Details
Main Authors: Siyue Lou, Hang Gao, Huanwu Hong, Zhihui Zhu, Huajun Zhao
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
RARα
Triple-negative breast cancer
Phosphorylation
miR-3074-5p
DHRS3
Online Access:https://doi.org/10.1186/s13046-021-01941-7

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