Wnt signaling inhibition confers induced synthetic lethality to PARP inhibitors
Despite considerable efforts, therapeutic strategies targeting the Wnt pathway are still not clinically available. The pervasive role of Wnt‐βcatenin signaling for the control of stem cells during normal tissue homeostasis makes the on‐target toxicity of available therapeutic grade molecules an impo...
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Online Access: | https://doi.org/10.15252/emmm.202114002 |
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doaj-46d751789d3941cf9f8eea0312b40f332021-08-02T23:22:27ZengWileyEMBO Molecular Medicine1757-46761757-46842021-04-01134n/an/a10.15252/emmm.202114002Wnt signaling inhibition confers induced synthetic lethality to PARP inhibitorsStephane Angers0Leslie Dan Faculty of Pharmacy University of Toronto Toronto ON CanadaDespite considerable efforts, therapeutic strategies targeting the Wnt pathway are still not clinically available. The pervasive role of Wnt‐βcatenin signaling for the control of stem cells during normal tissue homeostasis makes the on‐target toxicity of available therapeutic grade molecules an important limitation preventing their clinical introduction. The article in this issue of EMBO Molecular Medicine by Kaur et al (2021) reveals that treatment of Wnt‐addicted cancer cells with inhibitors of Wnt signaling induces a state of BRCAness leading to hypersensitivity to PARP inhibitors. This is a new example of induced synthetic lethality that could pave the way for new indications for PARP inhibitors or may contribute to the long‐awaited clinical introduction of therapeutic agents targeting the Wnt pathway.https://doi.org/10.15252/emmm.202114002 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stephane Angers |
spellingShingle |
Stephane Angers Wnt signaling inhibition confers induced synthetic lethality to PARP inhibitors EMBO Molecular Medicine |
author_facet |
Stephane Angers |
author_sort |
Stephane Angers |
title |
Wnt signaling inhibition confers induced synthetic lethality to PARP inhibitors |
title_short |
Wnt signaling inhibition confers induced synthetic lethality to PARP inhibitors |
title_full |
Wnt signaling inhibition confers induced synthetic lethality to PARP inhibitors |
title_fullStr |
Wnt signaling inhibition confers induced synthetic lethality to PARP inhibitors |
title_full_unstemmed |
Wnt signaling inhibition confers induced synthetic lethality to PARP inhibitors |
title_sort |
wnt signaling inhibition confers induced synthetic lethality to parp inhibitors |
publisher |
Wiley |
series |
EMBO Molecular Medicine |
issn |
1757-4676 1757-4684 |
publishDate |
2021-04-01 |
description |
Despite considerable efforts, therapeutic strategies targeting the Wnt pathway are still not clinically available. The pervasive role of Wnt‐βcatenin signaling for the control of stem cells during normal tissue homeostasis makes the on‐target toxicity of available therapeutic grade molecules an important limitation preventing their clinical introduction. The article in this issue of EMBO Molecular Medicine by Kaur et al (2021) reveals that treatment of Wnt‐addicted cancer cells with inhibitors of Wnt signaling induces a state of BRCAness leading to hypersensitivity to PARP inhibitors. This is a new example of induced synthetic lethality that could pave the way for new indications for PARP inhibitors or may contribute to the long‐awaited clinical introduction of therapeutic agents targeting the Wnt pathway. |
url |
https://doi.org/10.15252/emmm.202114002 |
work_keys_str_mv |
AT stephaneangers wntsignalinginhibitionconfersinducedsyntheticlethalitytoparpinhibitors |
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