Novel Antibiotics on the Horizon, 2015

• Main Author: Nazif ELALDI
• Format: Article
• Language: English
• Published: Bilimsel Tip Yayinevi 2015-03-01
• Series: Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi
• Subjects: Bacterial infections; Novel antibiotics
• Online Access: http://www.floradergisi.org/getFileContent.aspx?op=REDPDF&file_name=2015-20-01-001-009.pdf
• ISSN: 1300-932X; 1300-932X

The widespread use of antibiotics is relatively recent, extending back about 80 years. Inconvenient overuse of antibiotics and development of resistance in microorganisms are well known facts. Nowadays, even though organizations in many countries call for restrictions on antibiotic use, antibiotic resistance in the 21st century continues to be a major global problem and poses a threat to human life. In our country and in the world, infection prevalence of methicillin-resistant Staphylococcus aureus decreases, but prevalence of infection with extended spectrum beta-lactamase and carbapenemase producing enteric gram-negative bacilli is increasing rapidly. Antibiotic resistance in microorganisms has created a need for novel antibiotics. In the year 2010, “Infectious Diseases Society of America (IDSA)” supported a proGram, called “the ʹ10 × ʹ20ʹ initiative”, to develop ten new systemic antibacterial drugs until 2020. There have been more than 100 antibacterial agents developed for use in humans in the US since sulfonamides, but compared to previous years, there is deceleration in the development of new antibiotics today. Two systemic antibacterial agents have been approved for use in humans by the FDA from 2008 through 2012. Compare that to sixteen agents that were approved from 1983-1987. Since 2000, only four new classes of antibiotics have come on the market. These include oxazolidinones, pleuromutilin, lipopeptides and diarylquinolines. In this article, antibiotics recently accepted by organizations in the world and nominated for use in treatment of infections in humans in the future and ongoing clinical and laboratory research were discussed.