ZNF322A-mediated protein phosphorylation induces autophagosome formation through modulation of IRS1-AKT glucose uptake and HSP-elicited UPR in lung cancer

ZNF322A-mediated protein phosphorylation induces autophagosome formation through modulation of IRS1-AKT glucose uptake and HSP-elicited UPR in lung cancer

Abstract Background ZNF322A is an oncogenic transcription factor that belongs to the Cys2His2-type zinc-finger protein family. Accumulating evidence suggests that ZNF322A may contribute to the tumorigenesis of lung cancer, however, the ZNF322A-mediated downstream signaling pathways remain unknown. M...

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Bibliographic Details
Main Authors: Chantal Hoi Yin Cheung, Chia-Lang Hsu, Tsai-Yu Lin, Wei-Ting Chen, Yi-Ching Wang, Hsuan-Cheng Huang, Hsueh-Fen Juan
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Journal of Biomedical Science
Subjects:
Autophagy
Glucose starvation
Heat stress
Lung cancer
Phosphoproteomics
Proteomics
Online Access:http://link.springer.com/article/10.1186/s12929-020-00668-5

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