Tankyrase inhibition preserves osteoarthritic cartilage by coordinating cartilage matrix anabolism via effects on SOX9 PARylation

Tankyrase inhibition preserves osteoarthritic cartilage by coordinating cartilage matrix anabolism via effects on SOX9 PARylation

Osteoarthritis results from the progressive destruction of cartilage matrix. Here, Kim et al. identify tankyrase as a regulator of cartilage matrix anabolism, and find that tankyrase inhibition, by preventing SOX9 PARylation, protects from cartilage destruction in a mouse model of osteoarthritis.

Bibliographic Details
Main Authors: Sukyeong Kim, Sangbin Han, Yeongjae Kim, Hyeon-Seop Kim, Young-Ran Gu, Donghyun Kang, Yongsik Cho, Hyeonkyeong Kim, Jeeyeon Lee, Yeyoung Seo, Moon Jong Chang, Chong Bum Chang, Seung-Baik Kang, Jin-Hong Kim
Format: Article
Language:English
Published: Nature Publishing Group 2019-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12910-2

Internet

https://doi.org/10.1038/s41467-019-12910-2

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