5′UTR-mediated regulation of Ataxin-1 expression

5′UTR-mediated regulation of Ataxin-1 expression

Expression of mutant Ataxin-1 with an abnormally expanded polyglutamine domain is necessary for the onset and progression of spinocerebellar ataxia type 1 (SCA1). Understanding how Ataxin-1 expression is regulated in the human brain could inspire novel molecular therapies for this fatal, dominantly...

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Bibliographic Details
Main Authors:	Rachna Manek, Tiffany Nelson, Elizabeth Tseng, Edgardo Rodriguez-Lebron
Format:	Article
Language:	English
Published:	Elsevier 2020-02-01
Series:	Neurobiology of Disease
Subjects:	Spinocerebellar ataxia type 1 Ataxin-1 5′untranslated region Upstream AUG Post-transcriptional gene regulation Alternative splicing
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996119302323

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