Liquiritigenin protects against arsenic trioxide-induced liver injury by inhibiting oxidative stress and enhancing mTOR-mediated autophagy

Liquiritigenin protects against arsenic trioxide-induced liver injury by inhibiting oxidative stress and enhancing mTOR-mediated autophagy

Liquiritigenin (LQ) has protective effects against various hepatotoxicities. However, its specific role on arsenic trioxide (ATO)-induced hepatotoxicity and the related biomolecular mechanisms remain unclear. The purpose of this study is to explore the protective actions of LQ on ATO-induced hepatot...

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Bibliographic Details
Main Authors: Muqing Zhang, Yucong Xue, Bin Zheng, Li Li, Xi Chu, Yang Zhao, Yongchao Wu, Jianping Zhang, Xue Han, Zhonglin Wu, Li Chu
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Liquiritigenin
Arsenic trioxide
Oxidative stress
Inflammation
Autophagy
PI3K/AKT/mTOR
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221009513

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