Enhanced CXCR4 Expression of Human CD8Low T Lymphocytes Is Driven by S1P4

Enhanced CXCR4 Expression of Human CD8Low T Lymphocytes Is Driven by S1P4

Although the human immune response to cancer is naturally potent, it can be severely disrupted as a result of an immunosuppressive tumor microenvironment. Infiltrating regulatory T lymphocytes contribute to this immunosuppression by inhibiting proliferation of cytotoxic CD8+ T lymphocytes, which are...

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Bibliographic Details
Main Authors: Tobias Burkard, Caroline Dreis, Martina Herrero San Juan, Meik Huhn, Andreas Weigert, Josef M. Pfeilschifter, Heinfried H. Radeke
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
cytotoxic T lymphocyte
tumor immunity
IL-33
chemokines
sphingolipids
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.668884/full

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