Enhancing the function of CD34(+) cells by targeting plasminogen activator inhibitor-1.

Enhancing the function of CD34(+) cells by targeting plasminogen activator inhibitor-1.

Previously, we showed that transient inhibition of TGF- β1 resulted in correction of key aspects of diabetes-induced CD34(+) cell dysfunction. In this report, we examine the effect of transient inhibition of plasminogen activator inhibitor-1 (PAI-1), a major gene target of TGF-β1 activation. Using g...

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Bibliographic Details
Main Authors: Sugata Hazra, Valerie Stepps, Ashay D Bhatwadekar, Sergio Caballero, Michael E Boulton, Paul J Higgins, Elena V Nikonova, Carl J Pepine, Catherine Thut, Eva M Finney, David J Stone, Stephen H Bartelmez, Maria B Grant
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3815099?pdf=render

Internet

http://europepmc.org/articles/PMC3815099?pdf=render

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