Association between angiotensin-converting enzyme I/D polymorphism and sepsis: A meta-analysis

• Main Authors: Xin Hou, Pan Zhang, Wei Nie, Shunjuan Tang, Jiuyan Wang, Qiong Zhang, Zhengdong Wan, Botao Zhang, Bin Song
• Format: Article
• Language: English
• Published: Hindawi - SAGE Publishing 2015-06-01
• Series: Journal of the Renin-Angiotensin-Aldosterone System
• Online Access: https://doi.org/10.1177/1470320313492361
• ISSN: 1470-3203; 1752-8976

Background: Previous studies investigating the association between the angiotensin-converting enzyme I/D polymorphism and sepsis have provided inconsistent results. Thus, a meta-analysis was performed to clarify the effect of the angiotensin-converting enzyme I/D polymorphism on sepsis risk and sepsis-related mortality. Methods: A comprehensive literature search was performed. Six case–control studies and two cohort studies were included in this meta-analysis. Odds ratios and corresponding 95% confidence intervals were estimated using random-effects models. Results: Pooled analysis of six case–control studies showed that there was a significant association between the angiotensin-converting enzyme I/D polymorphism and sepsis risk in a recessive genetic model (odds ratio = 0.75, 95% confidence interval 0.62–0.91, p = 0.004). However, no significant association between the angiotensin-converting enzyme I/D polymorphism and mortality was observed (odds ratio = 0.84, 95% confidence interval 0.57–1.24, p = 0.38). Conclusions: Our meta-analysis confirmed that the angiotensin-converting enzyme I/D polymorphism was associated with sepsis risk. However, the angiotensin-converting enzyme I/D polymorphism was not associated with sepsis mortality.