Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis

Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis

In breast cancer, the loss of expression of WW domain-containing oxireductase (Wwox) has been observed. Here, the authors illustrate that in triple negative breast cancer models Wwox suppresses metastasis and proliferation via the JAK2/STAT3 pathway.

Bibliographic Details
Main Authors: Renxu Chang, Lele Song, Yi Xu, Yanjun Wu, Cheng Dai, Xinyu Wang, Xia Sun, Yingyong Hou, Wei Li, Xianbao Zhan, Lixing Zhan
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05852-8

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