Nitric oxide mediates stretch-induced Ca2+ release via activation of phosphatidylinositol 3-kinase-Akt pathway in smooth muscle.

Nitric oxide mediates stretch-induced Ca2+ release via activation of phosphatidylinositol 3-kinase-Akt pathway in smooth muscle.

Hollow smooth muscle organs such as the bladder undergo significant changes in wall tension associated with filling and distension, with attendant changes in muscle tone. Our previous study indicated that stretch induces Ca(2+) release occurs in the form of Ca(2+) sparks and Ca(2+) waves in urinary...

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Bibliographic Details
Main Authors: Bin Wei, Zheng Chen, Xu Zhang, Morris Feldman, Xian-zhi Dong, Robert Doran, Bao-Lu Zhao, Wen-xuan Yin, Michael I Kotlikoff, Guangju Ji
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2424173?pdf=render

Internet

http://europepmc.org/articles/PMC2424173?pdf=render

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