Enhanced lysosomal degradation maintains the quiescent state of neural stem cells

Enhanced lysosomal degradation maintains the quiescent state of neural stem cells

It remains unclear why quiescent neural stem cells (qNSCs) in the subventricular zone of the mouse brain have enlarged lysosomes. Here, authors demonstrate that qNSCs exhibit higher lysosomal activity and degrade activated EGF receptor by endolysosomal degradation more rapidly than proliferating NSC...

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Main Authors: Taeko Kobayashi, Wenhui Piao, Toshiya Takamura, Hiroshi Kori, Hitoshi Miyachi, Satsuki Kitano, Yumiko Iwamoto, Mayumi Yamada, Itaru Imayoshi, Seiji Shioda, Andrea Ballabio, Ryoichiro Kageyama
Format: Article
Language:English
Published: Nature Publishing Group 2019-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13203-4
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spelling doaj-4691a3fa38a34ed4b3aef31a734715362021-05-11T12:10:50ZengNature Publishing GroupNature Communications2041-17232019-11-0110111410.1038/s41467-019-13203-4Enhanced lysosomal degradation maintains the quiescent state of neural stem cellsTaeko Kobayashi0Wenhui Piao1Toshiya Takamura2Hiroshi Kori3Hitoshi Miyachi4Satsuki Kitano5Yumiko Iwamoto6Mayumi Yamada7Itaru Imayoshi8Seiji Shioda9Andrea Ballabio10Ryoichiro Kageyama11Institute for Frontier Life and Medical Sciences, Kyoto UniversityInstitute for Frontier Life and Medical Sciences, Kyoto UniversityInstitute for Frontier Life and Medical Sciences, Kyoto UniversityDepartment of Complexity Science and Engineering, University of TokyoInstitute for Frontier Life and Medical Sciences, Kyoto UniversityInstitute for Frontier Life and Medical Sciences, Kyoto UniversityInstitute for Frontier Life and Medical Sciences, Kyoto UniversityInstitute for Frontier Life and Medical Sciences, Kyoto UniversityInstitute for Frontier Life and Medical Sciences, Kyoto UniversityPeptide Drug Innovation, Global Research Center for Innovative Life Science (GRIL), Hoshi UniversityTelethon Institute of Genetics and MedicineInstitute for Frontier Life and Medical Sciences, Kyoto UniversityIt remains unclear why quiescent neural stem cells (qNSCs) in the subventricular zone of the mouse brain have enlarged lysosomes. Here, authors demonstrate that qNSCs exhibit higher lysosomal activity and degrade activated EGF receptor by endolysosomal degradation more rapidly than proliferating NSCs, which prevents the NSC exit from quiescence.https://doi.org/10.1038/s41467-019-13203-4
collection DOAJ
language English
format Article
sources DOAJ
author Taeko Kobayashi
Wenhui Piao
Toshiya Takamura
Hiroshi Kori
Hitoshi Miyachi
Satsuki Kitano
Yumiko Iwamoto
Mayumi Yamada
Itaru Imayoshi
Seiji Shioda
Andrea Ballabio
Ryoichiro Kageyama
spellingShingle Taeko Kobayashi
Wenhui Piao
Toshiya Takamura
Hiroshi Kori
Hitoshi Miyachi
Satsuki Kitano
Yumiko Iwamoto
Mayumi Yamada
Itaru Imayoshi
Seiji Shioda
Andrea Ballabio
Ryoichiro Kageyama
Enhanced lysosomal degradation maintains the quiescent state of neural stem cells
Nature Communications
author_facet Taeko Kobayashi
Wenhui Piao
Toshiya Takamura
Hiroshi Kori
Hitoshi Miyachi
Satsuki Kitano
Yumiko Iwamoto
Mayumi Yamada
Itaru Imayoshi
Seiji Shioda
Andrea Ballabio
Ryoichiro Kageyama
author_sort Taeko Kobayashi
title Enhanced lysosomal degradation maintains the quiescent state of neural stem cells
title_short Enhanced lysosomal degradation maintains the quiescent state of neural stem cells
title_full Enhanced lysosomal degradation maintains the quiescent state of neural stem cells
title_fullStr Enhanced lysosomal degradation maintains the quiescent state of neural stem cells
title_full_unstemmed Enhanced lysosomal degradation maintains the quiescent state of neural stem cells
title_sort enhanced lysosomal degradation maintains the quiescent state of neural stem cells
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-11-01
description It remains unclear why quiescent neural stem cells (qNSCs) in the subventricular zone of the mouse brain have enlarged lysosomes. Here, authors demonstrate that qNSCs exhibit higher lysosomal activity and degrade activated EGF receptor by endolysosomal degradation more rapidly than proliferating NSCs, which prevents the NSC exit from quiescence.
url https://doi.org/10.1038/s41467-019-13203-4
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AT toshiyatakamura enhancedlysosomaldegradationmaintainsthequiescentstateofneuralstemcells
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