Improved Methods for Thermal Rearrangement of Alicyclic α-Hydroxyimines to α-Aminoketones: Synthesis of Ketamine Analogues as Antisepsis Candidates

Improved Methods for Thermal Rearrangement of Alicyclic α-Hydroxyimines to α-Aminoketones: Synthesis of Ketamine Analogues as Antisepsis Candidates

Ketamine is an analgesic/anesthetic drug, which, in combination with other drugs, has been used as anesthetic for over 40 years. Ketamine induces its analgesic activities by blocking the <em>N</em>-methyl-D-aspartate (NMDA) receptor in the central nervous system (CNS). We...

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Bibliographic Details
Main Authors: Gerardo Byk, Hadar Eini, Hagit Elhawi, Amos Douvdevani
Format: Article
Language:English
Published: MDPI AG 2012-06-01
Series:Molecules
Subjects:
sepsis
IL-6
TNF-α
thermal rearrangement
α-amino-ketone
microwave
Online Access:http://www.mdpi.com/1420-3049/17/6/6784

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