Pentoxifylline improves the survival of spermatogenic cells via oxidative stress suppression and upregulation of PI3K/AKT pathway in mouse model of testicular torsion-detorsion

Pentoxifylline improves the survival of spermatogenic cells via oxidative stress suppression and upregulation of PI3K/AKT pathway in mouse model of testicular torsion-detorsion

Testicular torsion-detorsion results in enhanced formation of free radicals which contribute to the pathophysiology of testicular tissue damage. Recent reports have identified protective role of pentoxifylline (PTX) against free radicals. Thus, we determined the protective effect of pentoxifylline a...

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Bibliographic Details
Main Authors: Akanji Omotosho Dhulqarnain, Nasrin Takzaree, Golamreza Hassanzadeh, Heidar Tooli, Mehrnoush Malekzadeh, Nasrin Khanmohammadi, Mahsa Yaghobinejad, Somayeh Solhjoo, Tayebeh Rastegar
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Heliyon
Subjects:
Pentoxifylline
Testicular torsion-detorsion
Spermatogenesis
Oxidative stress
Antioxidant
PI3K/AKT pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844021009713

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http://www.sciencedirect.com/science/article/pii/S2405844021009713

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