Sialidase Deficiency in Porphyromonas gingivalis Increases IL-12 Secretion in Stimulated Macrophages Through Regulation of CR3, IncRNA GAS5 and miR-21

Sialidase Deficiency in Porphyromonas gingivalis Increases IL-12 Secretion in Stimulated Macrophages Through Regulation of CR3, IncRNA GAS5 and miR-21

Porphyromonas gingivalis (P. gingivalis) is a major periodontal pathogen that can induce an immune response leading to a destructive inflammatory process. During the inflammatory process, interleukin-12 (IL-12) is secreted, correlating with bacterial clearance by macrophages. Bacterial sialidase has...

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Bibliographic Details
Main Authors: Xue Yang, Yaping Pan, Xiaoyu Xu, Tong Tong, Shiwen Yu, Yue Zhao, Li Lin, Jingbo Liu, Dongmei Zhang, Chen Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
P. gingivalis
neuraminidase
macrophage
interleukin-12
microRNA-21
lncRNA GAS5
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2018.00100/full

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