RAD6B Plays a Critical Role in Neuronal DNA Damage Response to Resist Neurodegeneration

RAD6B Plays a Critical Role in Neuronal DNA Damage Response to Resist Neurodegeneration

RAD6 participates in DNA double-strand breaks (DSBs) repair by ubiquitinating histone H2B in mitotic cells. In terminally differentiated cells, however, the mechanisms of DNA damage repair are less well known. In this study, we investigate whether RAD6B is involved in DSBs repair in neurons and effe...

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Bibliographic Details
Main Authors: Zhao Guo, Yingxia Tian, Yingli Guo, Boya Li, Xiangwen Liu, Kun Xie, Yanfeng Song, Degui Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
RAD6B
aging
histone ubiquitination
DNA damage
neurodegeneration
senescence
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00392/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00392/full

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