Safety and tolerability of experimental hookworm infection in humans with metabolic disease: study protocol for a phase 1b randomised controlled clinical trial

Safety and tolerability of experimental hookworm infection in humans with metabolic disease: study protocol for a phase 1b randomised controlled clinical trial

Abstract Background Abdominal obesity and presence of the metabolic syndrome (MetS) significantly increase the risk of developing diseases such as Type 2 diabetes mellitus (T2DM) with escalating emergence of MetS and T2DM constituting a significant public health crisis worldwide. Lower prevalence of...

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Bibliographic Details
Main Authors: Doris Pierce, Lea Merone, Chris Lewis, Tony Rahman, John Croese, Alex Loukas, Malcolm McDonald, Paul Giacomin, Robyn McDermott
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Endocrine Disorders
Subjects:
Type 2 diabetes mellitus
Metabolic syndrome
Obesity
Necator americanus
Human microbiota
Type 2 immune response
Online Access:https://doi.org/10.1186/s12902-019-0461-5

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