Hepatoprotective Principles and Other Chemical Constituents from the Mycelium of Phellinus linteus

• Main Authors: Shiow-Chyn Huang, Pei-Wen Wang, Ping-Chung Kuo, Hsin-Yi Hung, Tai-Long Pan
• Format: Article
• Language: English
• Published: MDPI AG 2018-07-01
• Series: Molecules
• Subjects: Phellinus linteus; hepatic fibrosis; ionone derivative; spectroscopic and spectrometric analysis; hepatic stellate cell
• Online Access: http://www.mdpi.com/1420-3049/23/7/1705
• ISSN: 1420-3049

In the dimethylnitrosamine (DMN)-induced hepatic fibrosis Wistar rat model, the mycelium extract of Phellinus linteus (PLE) (20 mg/Kg) displayed significant protection against hepatic fibrosis. The present investigation characterized eleven new ionone derivatives, phellinulins D–N (4–14), from the P. linteus mycelium extract and the relative stereochemical structures were constructed according to the spectroscopic and spectrometric analytical results. Some purified compounds were examined for their inhibitory effects on activated rat hepatic stellate cells (HSCs) and several isolates did exhibit significant protection. The results indicated that the mycelium of P. linteus could be explored as a hepatoprotective drug or healthy food candidate in the near future.