New insights into YAP/TAZ nucleo‐cytoplasmic shuttling: new cancer therapeutic opportunities?

Yes‐associated protein (YAP) and transcriptional co‐activator with PDZ‐binding motif (TAZ), the main effectors of the Hippo pathway, are emerging as important players in cancer biology and therapy response. The intracellular localization of YAP/TAZ is a key determinant in the regulation of their act...

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Bibliographic Details
Main Authors: Michal Shreberk‐Shaked, Moshe Oren
Format: Article
Language:English
Published: Wiley 2019-06-01
Series:Molecular Oncology
Subjects:
TAZ
YAP
Online Access:https://doi.org/10.1002/1878-0261.12498