Substituted Hydroxyapatites with Antibacterial Properties

Reconstructive surgery is presently struggling with the problem of infections located within implantation biomaterials. Of course, the best antibacterial protection is antibiotic therapy. However, oral antibiotic therapy is sometimes ineffective, while administering an antibiotic at the location of...

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Main Authors: Joanna Kolmas, Ewa Groszyk, Dagmara Kwiatkowska-Różycka
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2014/178123
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spelling doaj-464d33c09768491181967d7ab7e970ab2020-11-24T23:04:28ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/178123178123Substituted Hydroxyapatites with Antibacterial PropertiesJoanna Kolmas0Ewa Groszyk1Dagmara Kwiatkowska-Różycka2Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Ul. Banacha 1, 02-097 Warsaw, PolandDepartment of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Ul. Banacha 1, 02-097 Warsaw, PolandDepartment of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Ul. Banacha 1, 02-097 Warsaw, PolandReconstructive surgery is presently struggling with the problem of infections located within implantation biomaterials. Of course, the best antibacterial protection is antibiotic therapy. However, oral antibiotic therapy is sometimes ineffective, while administering an antibiotic at the location of infection is often associated with an unfavourable ratio of dosage efficiency and toxic effect. Thus, the present study aims to find a new factor which may improve antibacterial activity while also presenting low toxicity to the human cells. Such factors are usually implemented along with the implant itself and may be an integral part of it. Many recent studies have focused on inorganic factors, such as metal nanoparticles, salts, and metal oxides. The advantages of inorganic factors include the ease with which they can be combined with ceramic and polymeric biomaterials. The following review focuses on hydroxyapatites substituted with ions with antibacterial properties. It considers materials that have already been applied in regenerative medicine (e.g., hydroxyapatites with silver ions) and those that are only at the preliminary stage of research and which could potentially be used in implantology or dentistry. We present methods for the synthesis of modified apatites and the antibacterial mechanisms of various ions as well as their antibacterial efficiency.http://dx.doi.org/10.1155/2014/178123
collection DOAJ
language English
format Article
sources DOAJ
author Joanna Kolmas
Ewa Groszyk
Dagmara Kwiatkowska-Różycka
spellingShingle Joanna Kolmas
Ewa Groszyk
Dagmara Kwiatkowska-Różycka
Substituted Hydroxyapatites with Antibacterial Properties
BioMed Research International
author_facet Joanna Kolmas
Ewa Groszyk
Dagmara Kwiatkowska-Różycka
author_sort Joanna Kolmas
title Substituted Hydroxyapatites with Antibacterial Properties
title_short Substituted Hydroxyapatites with Antibacterial Properties
title_full Substituted Hydroxyapatites with Antibacterial Properties
title_fullStr Substituted Hydroxyapatites with Antibacterial Properties
title_full_unstemmed Substituted Hydroxyapatites with Antibacterial Properties
title_sort substituted hydroxyapatites with antibacterial properties
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2014-01-01
description Reconstructive surgery is presently struggling with the problem of infections located within implantation biomaterials. Of course, the best antibacterial protection is antibiotic therapy. However, oral antibiotic therapy is sometimes ineffective, while administering an antibiotic at the location of infection is often associated with an unfavourable ratio of dosage efficiency and toxic effect. Thus, the present study aims to find a new factor which may improve antibacterial activity while also presenting low toxicity to the human cells. Such factors are usually implemented along with the implant itself and may be an integral part of it. Many recent studies have focused on inorganic factors, such as metal nanoparticles, salts, and metal oxides. The advantages of inorganic factors include the ease with which they can be combined with ceramic and polymeric biomaterials. The following review focuses on hydroxyapatites substituted with ions with antibacterial properties. It considers materials that have already been applied in regenerative medicine (e.g., hydroxyapatites with silver ions) and those that are only at the preliminary stage of research and which could potentially be used in implantology or dentistry. We present methods for the synthesis of modified apatites and the antibacterial mechanisms of various ions as well as their antibacterial efficiency.
url http://dx.doi.org/10.1155/2014/178123
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