The Rv3799-Rv3807 Gene Cluster in Genome Corresponds to the ‘Ancient Conserved Region’ in CMN Mycolyltransferases

The Rv3799-Rv3807 Gene Cluster in Genome Corresponds to the ‘Ancient Conserved Region’ in CMN Mycolyltransferases

We have identified based on gene cluster analysis that the genes between Rv3799–Rv3807 in M. tuberculosis have orthologs in Corynebacteria, Mycobacteria and Nocardia (CMN) genomes. Therefore, this gene cluster possibly corresponds to the ‘Ancient Conserved Region’ of CMN mycolyltransferases. The evo...

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Main Authors: Hemalatha G. Ramulu, Adindla Swathi, Lalitha Guruprasad
Format: Article
Language:English
Published: SAGE Publishing 2006-01-01
Series:Evolutionary Bioinformatics
Online Access:https://doi.org/10.1177/117693430600200015
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spelling doaj-463efa9624174d5f892c1688b11b62b12020-11-25T03:24:45ZengSAGE PublishingEvolutionary Bioinformatics1176-93432006-01-01210.1177/117693430600200015The Rv3799-Rv3807 Gene Cluster in Genome Corresponds to the ‘Ancient Conserved Region’ in CMN MycolyltransferasesHemalatha G. Ramulu0Adindla Swathi1Lalitha Guruprasad2School of Chemistry, University of Hyderabad, Hyderabad 500 046, India.School of Chemistry, University of Hyderabad, Hyderabad 500 046, India.School of Chemistry, University of Hyderabad, Hyderabad 500 046, India.We have identified based on gene cluster analysis that the genes between Rv3799–Rv3807 in M. tuberculosis have orthologs in Corynebacteria, Mycobacteria and Nocardia (CMN) genomes. Therefore, this gene cluster possibly corresponds to the ‘Ancient Conserved Region’ of CMN mycolyltransferases. The evolutionary trace analysis suggests that twelve amino acid residues; Leu39, Trp51, Pro71, Trp82, Trp97, Phe100, Gly124, Ser126, Asp192, Glu230, Gly260 and Trp264 are ‘absolutely conserved’. These amino acid residues constitute the active site and conserved hydrophobic tunnel in CMN mycolyltransferases.https://doi.org/10.1177/117693430600200015
collection DOAJ
language English
format Article
sources DOAJ
author Hemalatha G. Ramulu
Adindla Swathi
Lalitha Guruprasad
spellingShingle Hemalatha G. Ramulu
Adindla Swathi
Lalitha Guruprasad
The Rv3799-Rv3807 Gene Cluster in Genome Corresponds to the ‘Ancient Conserved Region’ in CMN Mycolyltransferases
Evolutionary Bioinformatics
author_facet Hemalatha G. Ramulu
Adindla Swathi
Lalitha Guruprasad
author_sort Hemalatha G. Ramulu
title The Rv3799-Rv3807 Gene Cluster in Genome Corresponds to the ‘Ancient Conserved Region’ in CMN Mycolyltransferases
title_short The Rv3799-Rv3807 Gene Cluster in Genome Corresponds to the ‘Ancient Conserved Region’ in CMN Mycolyltransferases
title_full The Rv3799-Rv3807 Gene Cluster in Genome Corresponds to the ‘Ancient Conserved Region’ in CMN Mycolyltransferases
title_fullStr The Rv3799-Rv3807 Gene Cluster in Genome Corresponds to the ‘Ancient Conserved Region’ in CMN Mycolyltransferases
title_full_unstemmed The Rv3799-Rv3807 Gene Cluster in Genome Corresponds to the ‘Ancient Conserved Region’ in CMN Mycolyltransferases
title_sort rv3799-rv3807 gene cluster in genome corresponds to the ‘ancient conserved region’ in cmn mycolyltransferases
publisher SAGE Publishing
series Evolutionary Bioinformatics
issn 1176-9343
publishDate 2006-01-01
description We have identified based on gene cluster analysis that the genes between Rv3799–Rv3807 in M. tuberculosis have orthologs in Corynebacteria, Mycobacteria and Nocardia (CMN) genomes. Therefore, this gene cluster possibly corresponds to the ‘Ancient Conserved Region’ of CMN mycolyltransferases. The evolutionary trace analysis suggests that twelve amino acid residues; Leu39, Trp51, Pro71, Trp82, Trp97, Phe100, Gly124, Ser126, Asp192, Glu230, Gly260 and Trp264 are ‘absolutely conserved’. These amino acid residues constitute the active site and conserved hydrophobic tunnel in CMN mycolyltransferases.
url https://doi.org/10.1177/117693430600200015
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