Intrinsic Nucleotide Preference of Diversifying Base Editors Guides Antibody Ex Vivo Affinity Maturation

Intrinsic Nucleotide Preference of Diversifying Base Editors Guides Antibody Ex Vivo Affinity Maturation

Summary: Base editors (BEs) are emerging tools used for precision correction or diversifying mutation. It provides a potential way to recreate somatic hypermutations (SHM) for generating high-affinity antibody, which is usually screened from antigen-challenged animal models or synthetic combinatoria...

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Bibliographic Details
Main Authors: Liu Daisy Liu, Min Huang, Pengfei Dai, Tingting Liu, Shuangshuang Fan, Xueqian Cheng, Yaofeng Zhao, Leng-Siew Yeap, Fei-Long Meng
Format: Article
Language:English
Published: Elsevier 2018-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718315614

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