Current Perspective in the Discovery of Anti-aging Agents from Natural Products

• Main Authors: Ai-Jun Ding, Shan-Qing Zheng, Xiao-Bing Huang, Ti-Kun Xing, Gui-Sheng Wu, Hua-Ying Sun, Shu-Hua Qi, Huai-Rong Luo
• Format: Article
• Language: English
• Published: SpringerOpen 2017-05-01
• Series: Natural Products and Bioprospecting
• Subjects: Aging; Natural products; Anti-aging; Drug screening
• Online Access: http://link.springer.com/article/10.1007/s13659-017-0135-9

Abstract Aging is a process characterized by accumulating degenerative damages, resulting in the death of an organism ultimately. The main goal of aging research is to develop therapies that delay age-related diseases in human. Since signaling pathways in aging of Caenorhabditis elegans (C. elegans), fruit flies and mice are evolutionarily conserved, compounds extending lifespan of them by intervening pathways of aging may be useful in treating age-related diseases in human. Natural products have special resource advantage and with few side effect. Recently, many compounds or extracts from natural products slowing aging and extending lifespan have been reported. Here we summarized these compounds or extracts and their mechanisms in increasing longevity of C. elegans or other species, and the prospect in developing anti-aging medicine from natural products.