Facile acylation of glycerophosphocholine catalyzed by trifluoroacetic anhydride.

A simplified procedure for the synthesis of short acyl chain phosphatidylcholines is described. A mixed fatty acid-trifluoroacetic anhydride is used to acylate sn-glycero-3-phosphocholine (GPC) which has been dissolved in trifluoroacetic acid. Yields exceeding 70% are achieved in 30-min reaction tim...

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Main Authors:	P Kanda, M A Wells
Format:	Article
Language:	English
Published:	Elsevier 1981-07-01
Series:	Journal of Lipid Research
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520373612

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spelling	doaj-4630ab0b2722433192a216556afc08d62021-04-24T05:50:11ZengElsevierJournal of Lipid Research0022-22751981-07-01225877879Facile acylation of glycerophosphocholine catalyzed by trifluoroacetic anhydride.P KandaM A WellsA simplified procedure for the synthesis of short acyl chain phosphatidylcholines is described. A mixed fatty acid-trifluoroacetic anhydride is used to acylate sn-glycero-3-phosphocholine (GPC) which has been dissolved in trifluoroacetic acid. Yields exceeding 70% are achieved in 30-min reaction time using 1.5 to 2.0 equivalents of mixed anhydride per, GPC hydroxyl. This allows a more economical use of labeled short chain acids.http://www.sciencedirect.com/science/article/pii/S0022227520373612
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	P Kanda M A Wells
spellingShingle	P Kanda M A Wells Facile acylation of glycerophosphocholine catalyzed by trifluoroacetic anhydride. Journal of Lipid Research
author_facet	P Kanda M A Wells
author_sort	P Kanda
title	Facile acylation of glycerophosphocholine catalyzed by trifluoroacetic anhydride.
title_short	Facile acylation of glycerophosphocholine catalyzed by trifluoroacetic anhydride.
title_full	Facile acylation of glycerophosphocholine catalyzed by trifluoroacetic anhydride.
title_fullStr	Facile acylation of glycerophosphocholine catalyzed by trifluoroacetic anhydride.
title_full_unstemmed	Facile acylation of glycerophosphocholine catalyzed by trifluoroacetic anhydride.
title_sort	facile acylation of glycerophosphocholine catalyzed by trifluoroacetic anhydride.
publisher	Elsevier
series	Journal of Lipid Research
issn	0022-2275
publishDate	1981-07-01
description	A simplified procedure for the synthesis of short acyl chain phosphatidylcholines is described. A mixed fatty acid-trifluoroacetic anhydride is used to acylate sn-glycero-3-phosphocholine (GPC) which has been dissolved in trifluoroacetic acid. Yields exceeding 70% are achieved in 30-min reaction time using 1.5 to 2.0 equivalents of mixed anhydride per, GPC hydroxyl. This allows a more economical use of labeled short chain acids.
url	http://www.sciencedirect.com/science/article/pii/S0022227520373612
work_keys_str_mv	AT pkanda facileacylationofglycerophosphocholinecatalyzedbytrifluoroaceticanhydride AT mawells facileacylationofglycerophosphocholinecatalyzedbytrifluoroaceticanhydride
_version_	1721511785856499712

Facile acylation of glycerophosphocholine catalyzed by trifluoroacetic anhydride.

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