Insights into the Voltage Regulation Mechanism of the Pore-Forming Toxin Lysenin

Insights into the Voltage Regulation Mechanism of the Pore-Forming Toxin Lysenin

Lysenin, a pore forming toxin (PFT) extracted from Eisenia fetida, inserts voltage-regulated channels into artificial lipid membranes containing sphingomyelin. The voltage-induced gating leads to a strong static hysteresis in conductance, which endows lysenin with molecular memory capabilities. To e...

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Bibliographic Details
Main Authors: Sheenah Lynn Bryant, Tyler Clark, Christopher Alex Thomas, Kaitlyn Summer Ware, Andrew Bogard, Colleen Calzacorta, Daniel Prather, Daniel Fologea
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Toxins
Subjects:
lysenin
pore forming toxins
voltage gating
hysteresis
electrostatic screening
Online Access:http://www.mdpi.com/2072-6651/10/8/334

Internet

http://www.mdpi.com/2072-6651/10/8/334

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