Potentiometric Determination of Minoxidil in Topical Use Pharmaceutical Samples

Potentiometric Determination of Minoxidil in Topical Use Pharmaceutical Samples

A potentiometric titration method for the determination of minoxidil based on its redox reaction with K2Cr2O7 is described. The best results were observed using 1.00 x 10-3 mol L-1 K2Cr2O7 and 1.00 x 10-2 mol L-1 minoxidil solutions, and the minoxidil as titrant in 2.00 mol L-1 H2SO4 medium. The met...

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Main Authors: Rogério Adelino de Sousa, Éder Tadeu Gomes Cavalheiro
Format: Article
Language:English
Published: Universidade Estadual Paulista 2018-04-01
Series:Eclética Química
Online Access:https://revista.iq.unesp.br/ojs/index.php/ecletica/article/view/259
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spelling doaj-462b339d8d0c4190a4b92dfa2f43553d2020-11-25T00:17:28ZengUniversidade Estadual PaulistaEclética Química1678-46182018-04-01342232710.26850/1678-4618eqj.v34.2.2009.p23-27259Potentiometric Determination of Minoxidil in Topical Use Pharmaceutical SamplesRogério Adelino de Sousa0Éder Tadeu Gomes Cavalheiro1Departamento de Química, Universidade Federal de São CarlosDepartamento de Química e Física Molecular, Instituto de Química de São Carlos, Universidade de São PauloA potentiometric titration method for the determination of minoxidil based on its redox reaction with K2Cr2O7 is described. The best results were observed using 1.00 x 10-3 mol L-1 K2Cr2O7 and 1.00 x 10-2 mol L-1 minoxidil solutions, and the minoxidil as titrant in 2.00 mol L-1 H2SO4 medium. The method was applied to commercial samples and compared with the results from a chromatographic procedure. Recoveries from 97.4 to 98.7 % were observed depending on the sample. Comparison with the chromatographic procedure reveled agreement within 90% confidence level.https://revista.iq.unesp.br/ojs/index.php/ecletica/article/view/259
collection DOAJ
language English
format Article
sources DOAJ
author Rogério Adelino de Sousa
Éder Tadeu Gomes Cavalheiro
spellingShingle Rogério Adelino de Sousa
Éder Tadeu Gomes Cavalheiro
Potentiometric Determination of Minoxidil in Topical Use Pharmaceutical Samples
Eclética Química
author_facet Rogério Adelino de Sousa
Éder Tadeu Gomes Cavalheiro
author_sort Rogério Adelino de Sousa
title Potentiometric Determination of Minoxidil in Topical Use Pharmaceutical Samples
title_short Potentiometric Determination of Minoxidil in Topical Use Pharmaceutical Samples
title_full Potentiometric Determination of Minoxidil in Topical Use Pharmaceutical Samples
title_fullStr Potentiometric Determination of Minoxidil in Topical Use Pharmaceutical Samples
title_full_unstemmed Potentiometric Determination of Minoxidil in Topical Use Pharmaceutical Samples
title_sort potentiometric determination of minoxidil in topical use pharmaceutical samples
publisher Universidade Estadual Paulista
series Eclética Química
issn 1678-4618
publishDate 2018-04-01
description A potentiometric titration method for the determination of minoxidil based on its redox reaction with K2Cr2O7 is described. The best results were observed using 1.00 x 10-3 mol L-1 K2Cr2O7 and 1.00 x 10-2 mol L-1 minoxidil solutions, and the minoxidil as titrant in 2.00 mol L-1 H2SO4 medium. The method was applied to commercial samples and compared with the results from a chromatographic procedure. Recoveries from 97.4 to 98.7 % were observed depending on the sample. Comparison with the chromatographic procedure reveled agreement within 90% confidence level.
url https://revista.iq.unesp.br/ojs/index.php/ecletica/article/view/259
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AT edertadeugomescavalheiro potentiometricdeterminationofminoxidilintopicalusepharmaceuticalsamples
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