Ultratrace element contents in rat tissues: Comparative analysis of serum and hair as indicative matrices of the total body burden

• Main Authors: Skalny Anatoly V., Tinkov Alexey A., Skalny Andrey A., Medvedeva Yulia S., Alchinova Irina B., Ajsuvakova Olga P., Karganov Mikhail Yu., Nikonorov Alexandr A.
• Format: Article
• Language: English
• Published: University of Belgrade, University of Novi Sad 2016-01-01
• Series: Archives of Biological Sciences
• Subjects: ultratrace elements; inductively coupled plasma mass spectrometry; rats; hair; chow
• Online Access: http://www.doiserbia.nb.rs/img/doi/0354-4664/2016/0354-46641600053S.pdf
• ISSN: 0354-4664; 1821-4339

The aim of this study was to investigate the distribution of ultratrace elements in rat tissues and to perform a comparative analysis of hair and serum as potential bioindicators of the total ultratrace element content. Thirty-six male Wistar rats were fed a standard chow containing 0.006±0.000, 0.001±0.000, 0.017±0.002, 0.382±0.031, 0.168±0.014, 3.211±0.134, 0.095±0.006, 0.000±0.000, 6.675±0.336, 15.327±0.564, 0.002±0.000, and 1.185±0.202 μg/g of silver (Ag), gold (Au), cesium (Cs), gallium (Ga), germanium (Ge), lanthanum (La), niobium (Nb), platinum (Pt), rubidium (Rb), titanium (Ti), thallium (Tl)and zirconium (Zr), respectively, from weaning to 3 months old. The ultratrace element content in the liver, kidney, muscle, heart, serum and hair was assessed using inductively coupled plasma mass spectrometry. The obtained data indicate that the highest concentrations of most of the studied elements (Ti, Zr, Ge, Nb, tungsten (W), La, uranium (U), Ag, Au, Pt) are in hair, whereas the lowest were observed in the serum. Statistical analysis revealed a significant association between concentrations in the hair and other tissues for Cs, Ti, Nb, Tl, La, U and Au. At the same time, serum Cs, Rb, Ti, Ge, Nb, W, Ga, Tl and La concentrations significantly correlated with the tissue content of the respective ultratrace elements. It can be concluded that hair may be used as a potential bioindicator for certain ultratrace element content in the mammalian organism.