FoxP2 isoforms delineate spatiotemporal transcriptional networks for vocal learning in the zebra finch

Human speech is one of the few examples of vocal learning among mammals yet ~half of avian species exhibit this ability. Its neurogenetic basis is largely unknown beyond a shared requirement for FoxP2 in both humans and zebra finches. We manipulated FoxP2 isoforms in Area X, a song-specific region o...

Full description

Bibliographic Details
Main Authors:	Zachary Daniel Burkett, Nancy F Day, Todd Haswell Kimball, Caitlin M Aamodt, Jonathan B Heston, Austin T Hilliard, Xinshu Xiao, Stephanie A White
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2018-01-01
Series:	eLife
Subjects:	Taeniopygia guttata WGCNA Area X RNA-seq vocal learning
Online Access:	https://elifesciences.org/articles/30649

id	doaj-4627c219655f425eb12bc073f66fdd02
record_format	Article
spelling	doaj-4627c219655f425eb12bc073f66fdd022021-05-05T15:32:34ZengeLife Sciences Publications LtdeLife2050-084X2018-01-01710.7554/eLife.30649FoxP2 isoforms delineate spatiotemporal transcriptional networks for vocal learning in the zebra finchZachary Daniel Burkett0https://orcid.org/0000-0002-5153-485XNancy F Day1https://orcid.org/0000-0001-5367-9473Todd Haswell Kimball2Caitlin M Aamodt3Jonathan B Heston4https://orcid.org/0000-0001-7479-1122Austin T Hilliard5Xinshu Xiao6Stephanie A White7https://orcid.org/0000-0002-3490-2294Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, United States; Interdepartmental Program in Molecular, Cellular, and Integrative Physiology, University of California, Los Angeles, Los Angeles, United StatesDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, United StatesDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, United States; Physiological Science Master’s Degree Program, University of California, Los Angeles, Los Angeles, United StatesDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, United States; Interdepartmental Program in Neuroscience, University of California, Los Angeles, Los Angeles, United StatesDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, United States; Interdepartmental Program in Neuroscience, University of California, Los Angeles, Los Angeles, United StatesDepartment of Biology, Stanford University, Stanford, Stanford, United StatesDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, United States; Interdepartmental Program in Molecular, Cellular, and Integrative Physiology, University of California, Los Angeles, Los Angeles, United StatesDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, United States; Interdepartmental Program in Molecular, Cellular, and Integrative Physiology, University of California, Los Angeles, Los Angeles, United States; Interdepartmental Program in Neuroscience, University of California, Los Angeles, Los Angeles, United StatesHuman speech is one of the few examples of vocal learning among mammals yet ~half of avian species exhibit this ability. Its neurogenetic basis is largely unknown beyond a shared requirement for FoxP2 in both humans and zebra finches. We manipulated FoxP2 isoforms in Area X, a song-specific region of the avian striatopallidum analogous to human anterior striatum, during a critical period for song development. We delineate, for the first time, unique contributions of each isoform to vocal learning. Weighted gene coexpression network analysis of RNA-seq data revealed gene modules correlated to singing, learning, or vocal variability. Coexpression related to singing was found in juvenile and adult Area X whereas coexpression correlated to learning was unique to juveniles. The confluence of learning and singing coexpression in juvenile Area X may underscore molecular processes that drive vocal learning in young zebra finches and, by analogy, humans.https://elifesciences.org/articles/30649Taeniopygia guttataWGCNAArea XRNA-seqvocal learning
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Zachary Daniel Burkett Nancy F Day Todd Haswell Kimball Caitlin M Aamodt Jonathan B Heston Austin T Hilliard Xinshu Xiao Stephanie A White
spellingShingle	Zachary Daniel Burkett Nancy F Day Todd Haswell Kimball Caitlin M Aamodt Jonathan B Heston Austin T Hilliard Xinshu Xiao Stephanie A White FoxP2 isoforms delineate spatiotemporal transcriptional networks for vocal learning in the zebra finch eLife Taeniopygia guttata WGCNA Area X RNA-seq vocal learning
author_facet	Zachary Daniel Burkett Nancy F Day Todd Haswell Kimball Caitlin M Aamodt Jonathan B Heston Austin T Hilliard Xinshu Xiao Stephanie A White
author_sort	Zachary Daniel Burkett
title	FoxP2 isoforms delineate spatiotemporal transcriptional networks for vocal learning in the zebra finch
title_short	FoxP2 isoforms delineate spatiotemporal transcriptional networks for vocal learning in the zebra finch
title_full	FoxP2 isoforms delineate spatiotemporal transcriptional networks for vocal learning in the zebra finch
title_fullStr	FoxP2 isoforms delineate spatiotemporal transcriptional networks for vocal learning in the zebra finch
title_full_unstemmed	FoxP2 isoforms delineate spatiotemporal transcriptional networks for vocal learning in the zebra finch
title_sort	foxp2 isoforms delineate spatiotemporal transcriptional networks for vocal learning in the zebra finch
publisher	eLife Sciences Publications Ltd
series	eLife
issn	2050-084X
publishDate	2018-01-01
description	Human speech is one of the few examples of vocal learning among mammals yet ~half of avian species exhibit this ability. Its neurogenetic basis is largely unknown beyond a shared requirement for FoxP2 in both humans and zebra finches. We manipulated FoxP2 isoforms in Area X, a song-specific region of the avian striatopallidum analogous to human anterior striatum, during a critical period for song development. We delineate, for the first time, unique contributions of each isoform to vocal learning. Weighted gene coexpression network analysis of RNA-seq data revealed gene modules correlated to singing, learning, or vocal variability. Coexpression related to singing was found in juvenile and adult Area X whereas coexpression correlated to learning was unique to juveniles. The confluence of learning and singing coexpression in juvenile Area X may underscore molecular processes that drive vocal learning in young zebra finches and, by analogy, humans.
topic	Taeniopygia guttata WGCNA Area X RNA-seq vocal learning
url	https://elifesciences.org/articles/30649
work_keys_str_mv	AT zacharydanielburkett foxp2isoformsdelineatespatiotemporaltranscriptionalnetworksforvocallearninginthezebrafinch AT nancyfday foxp2isoformsdelineatespatiotemporaltranscriptionalnetworksforvocallearninginthezebrafinch AT toddhaswellkimball foxp2isoformsdelineatespatiotemporaltranscriptionalnetworksforvocallearninginthezebrafinch AT caitlinmaamodt foxp2isoformsdelineatespatiotemporaltranscriptionalnetworksforvocallearninginthezebrafinch AT jonathanbheston foxp2isoformsdelineatespatiotemporaltranscriptionalnetworksforvocallearninginthezebrafinch AT austinthilliard foxp2isoformsdelineatespatiotemporaltranscriptionalnetworksforvocallearninginthezebrafinch AT xinshuxiao foxp2isoformsdelineatespatiotemporaltranscriptionalnetworksforvocallearninginthezebrafinch AT stephanieawhite foxp2isoformsdelineatespatiotemporaltranscriptionalnetworksforvocallearninginthezebrafinch
_version_	1721459885830307840

FoxP2 isoforms delineate spatiotemporal transcriptional networks for vocal learning in the zebra finch

Similar Items