Persistence of the reproductive toxicity of chlorpiryphos-ethyl in male Wistar rat

Objective: To study the effects of chlorpiryphos-ethyl (CE) on male fertility. Methods: Rats were gavaged daily from 30 to 120 days old with four doses of CE (10.50; 5.25; 3.50 and 0.00 mg/kg) and thereafter followed up for 90 additional days. Following this period of observation, each male rat was...

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Main Authors: Augustave Kenfack, Ferdinand Ngoula, Paul Désiré Womeni Dzeufiet, Omer Bébé Ngouateu, Tsambou Megnimeza Astride Martine, Judith Kegne Chombong, Guylène Marie Zambou Zeukeng, Isabelle Leinyuy Nyuysemo, Arthenice Jemima Noumamo Guiekep, Tah Patience Nain, Pierre Kamtchouing, Joseph Tchoumbou, Narcisse Bertin Vemo
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2015-03-01
Series:Asian Pacific Journal of Reproduction
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2305050014600555
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spelling doaj-4625430063354688b8e82cf109911e3d2020-11-24T22:01:42ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Reproduction2305-05002015-03-0141374010.1016/S2305-0500(14)60055-5Persistence of the reproductive toxicity of chlorpiryphos-ethyl in male Wistar ratAugustave Kenfack0Ferdinand Ngoula1Paul Désiré Womeni Dzeufiet2Omer Bébé Ngouateu3Tsambou Megnimeza Astride Martine4Judith Kegne Chombong5Guylène Marie Zambou Zeukeng6Isabelle Leinyuy Nyuysemo7Arthenice Jemima Noumamo Guiekep8Tah Patience Nain9Pierre Kamtchouing10Joseph Tchoumbou11Narcisse Bertin Vemo12University of Dschang, Faculty of Agronomy and Agricultural Sciences, Department of Animal Production, Dschang, CameroonUniversity of Dschang, Faculty of Agronomy and Agricultural Sciences, Department of Animal Production, Dschang, CameroonUniversity of Yaoundé I, Faculty of Sciences, Department of Animal Biology and Physiology, Yaoundé, CameroonUniversity of Yaoundé I, Faculty of Sciences, Department of Animal Biology and Physiology, Yaoundé, CameroonUniversity of Dschang, Faculty of Agronomy and Agricultural Sciences, Department of Animal Production, Dschang, CameroonUniversity of Dschang, Faculty of Agronomy and Agricultural Sciences, Department of Animal Production, Dschang, CameroonUniversity of Dschang, Faculty of Agronomy and Agricultural Sciences, Department of Animal Production, Dschang, CameroonIrad Bambui, Bambui, CameroonUniversity of Dschang, Faculty of Agronomy and Agricultural Sciences, Department of Animal Production, Dschang, CameroonUniversity of Dschang, Faculty of Agronomy and Agricultural Sciences, Department of Animal Production, Dschang, CameroonUniversity of Yaoundé I, Faculty of Sciences, Department of Animal Biology and Physiology, Yaoundé, CameroonUniversity of Dschang, Faculty of Agronomy and Agricultural Sciences, Department of Animal Production, Dschang, CameroonUniversity of Dschang, Faculty of Agronomy and Agricultural Sciences, Department of Animal Production, Dschang, CameroonObjective: To study the effects of chlorpiryphos-ethyl (CE) on male fertility. Methods: Rats were gavaged daily from 30 to 120 days old with four doses of CE (10.50; 5.25; 3.50 and 0.00 mg/kg) and thereafter followed up for 90 additional days. Following this period of observation, each male rat was submitted to a fertility test with two virgin females. Male were then sacrificed and organs collected while females were followed up till delivery. Results: The weights of the testis and epididymis were lower (P<0.05) in rats treated with 10.50 mg/kg CE dose compared to controls. A decrease in the number of sperm per cauda epididymis was recorded in rat given the highest dose of CE with respect to the control value. The sperm motility was lower (P<0.05) in all CE-treated groups compared to the controls. Severe histological abnormalities were observed in testes of treated rats. The males exposed to the highest dose of CE did not produce any offspring. Conclusion: The effects of CE on reproductive system were persistent 90 days after the end of exposure.http://www.sciencedirect.com/science/article/pii/S2305050014600555Chlorpiryphos-ethylMale fertilityWistar ratPersistent effects
collection DOAJ
language English
format Article
sources DOAJ
author Augustave Kenfack
Ferdinand Ngoula
Paul Désiré Womeni Dzeufiet
Omer Bébé Ngouateu
Tsambou Megnimeza Astride Martine
Judith Kegne Chombong
Guylène Marie Zambou Zeukeng
Isabelle Leinyuy Nyuysemo
Arthenice Jemima Noumamo Guiekep
Tah Patience Nain
Pierre Kamtchouing
Joseph Tchoumbou
Narcisse Bertin Vemo
spellingShingle Augustave Kenfack
Ferdinand Ngoula
Paul Désiré Womeni Dzeufiet
Omer Bébé Ngouateu
Tsambou Megnimeza Astride Martine
Judith Kegne Chombong
Guylène Marie Zambou Zeukeng
Isabelle Leinyuy Nyuysemo
Arthenice Jemima Noumamo Guiekep
Tah Patience Nain
Pierre Kamtchouing
Joseph Tchoumbou
Narcisse Bertin Vemo
Persistence of the reproductive toxicity of chlorpiryphos-ethyl in male Wistar rat
Asian Pacific Journal of Reproduction
Chlorpiryphos-ethyl
Male fertility
Wistar rat
Persistent effects
author_facet Augustave Kenfack
Ferdinand Ngoula
Paul Désiré Womeni Dzeufiet
Omer Bébé Ngouateu
Tsambou Megnimeza Astride Martine
Judith Kegne Chombong
Guylène Marie Zambou Zeukeng
Isabelle Leinyuy Nyuysemo
Arthenice Jemima Noumamo Guiekep
Tah Patience Nain
Pierre Kamtchouing
Joseph Tchoumbou
Narcisse Bertin Vemo
author_sort Augustave Kenfack
title Persistence of the reproductive toxicity of chlorpiryphos-ethyl in male Wistar rat
title_short Persistence of the reproductive toxicity of chlorpiryphos-ethyl in male Wistar rat
title_full Persistence of the reproductive toxicity of chlorpiryphos-ethyl in male Wistar rat
title_fullStr Persistence of the reproductive toxicity of chlorpiryphos-ethyl in male Wistar rat
title_full_unstemmed Persistence of the reproductive toxicity of chlorpiryphos-ethyl in male Wistar rat
title_sort persistence of the reproductive toxicity of chlorpiryphos-ethyl in male wistar rat
publisher Wolters Kluwer Medknow Publications
series Asian Pacific Journal of Reproduction
issn 2305-0500
publishDate 2015-03-01
description Objective: To study the effects of chlorpiryphos-ethyl (CE) on male fertility. Methods: Rats were gavaged daily from 30 to 120 days old with four doses of CE (10.50; 5.25; 3.50 and 0.00 mg/kg) and thereafter followed up for 90 additional days. Following this period of observation, each male rat was submitted to a fertility test with two virgin females. Male were then sacrificed and organs collected while females were followed up till delivery. Results: The weights of the testis and epididymis were lower (P<0.05) in rats treated with 10.50 mg/kg CE dose compared to controls. A decrease in the number of sperm per cauda epididymis was recorded in rat given the highest dose of CE with respect to the control value. The sperm motility was lower (P<0.05) in all CE-treated groups compared to the controls. Severe histological abnormalities were observed in testes of treated rats. The males exposed to the highest dose of CE did not produce any offspring. Conclusion: The effects of CE on reproductive system were persistent 90 days after the end of exposure.
topic Chlorpiryphos-ethyl
Male fertility
Wistar rat
Persistent effects
url http://www.sciencedirect.com/science/article/pii/S2305050014600555
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