In vitro fertilization as a method of infertility treatment in women with type 1 diabetes mellitus

• Main Authors: Elena V. Misharina, Alena V. Tiselko, Maria I. Yarmolinskaya, Igor U. Kogan, Elena I. Abashova, Natalia V. Borovik
• Format: Article
• Language: English
• Published: Endocrinology Research Centre 2018-12-01
• Series: Сахарный диабет
• Subjects: diabetes mellitus type 1; pregnancy; assisted reproduction; ivf; continuous subcutaneous infusion of insulin; case report
• Online Access: https://dia-endojournals.ru/dia/article/viewFile/9573/pdf_1
• ISSN: 2072-0351; 2072-0378

Some patients with type 1 diabetes have anovulation, tubal occlusion, male factor and other causes of infertility which require IVF procedure. We examined 20 women with type 1 diabetes, in which pregnancy occurred as a result of ART, at the stage IVF protocol planning, during pregnancy course and delivery. One of the patients underwent IVF procedure twice. Mean age of the patients who applied to the Department of assisted reproductive technologies was 336 years, duration of infertility varied from 3 to 15 years. Two patients were performed donor oocytes transfer (patients with Turner Syndrome and Swyer Syndrome). In 70% of patients the method of CSII was used. Assessment of carbohydrate metabolism was based on the level of glycated hemoglobin A1c (HbA1c), plasma glucose level measured at least 8 times a day and results of continuous glucose monitoring (CGM). 18 singleton pregnancies and three multiple gestations (dichorionic diamniotic twins) occurred as a result of IVF. In 12 women delivery occurred on the 3739th weeks of gestation, in 9 patients pregnancy was terminated on the 3436th weeks. In all the cases it was live birth. Birth weight above the 90th percentile had 6 newborns.