An Effective and Safe Enkephalin Analog for Antinociception

An Effective and Safe Enkephalin Analog for Antinociception

Opioids account for 69,000 overdose deaths per annum worldwide and cause serious side effects. Safer analgesics are urgently needed. The endogenous opioid peptide Leu-Enkephalin (Leu-ENK) is ineffective when introduced peripherally due to poor stability and limited membrane permeability. We develope...

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Bibliographic Details
Main Authors: K. K. DurgaRao Viswanadham, Roland Böttger, Lukas Hohenwarter, Anne Nguyen, Elham Rouhollahi, Alexander Smith, Yi-Hsuan Tsai, Yuan-Yu Chang, Christopher Llynard Ortiz, Lee-Wei Yang, Liliana Jimenez, Siyuan Li, Chan Hur, Shyh-Dar Li
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pharmaceutics
Subjects:
enkephalin
pain
analgesics
dependence
tolerance
respiratory suppression
Online Access:https://www.mdpi.com/1999-4923/13/7/927

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https://www.mdpi.com/1999-4923/13/7/927

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