Cardioprotection by kappa-opioid receptor agonist U50488H is mediated by opioidergic regulation but not by calcium current modulation

Cardioprotection by kappa-opioid receptor agonist U50488H is mediated by opioidergic regulation but not by calcium current modulation

BackgroundBecause the κ-opioid receptor (OR) agonist U50488H stimulates opioidergic regulation and inhibits L-type Ca2+ channels, this study was aimed at assessing the roles of OR and L-type Ca2+ channels on U50488H-induced cardioprotection.MethodsLangendorff-perfused rat hearts were subjected to 30...

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Bibliographic Details
Main Authors: Kook Jin Chun, Young Ho Jang, June Hong Kim, Jun Kim, Yong Hyun Park
Format: Article
Language:English
Published: Korean Society of Anesthesiologists 2010-02-01
Series:Korean Journal of Anesthesiology
Subjects:
coronary occlusion
myocardial infarction
opioid receptors
reperfusion
Online Access:http://ekja.org/upload/pdf/kjae-58-162.pdf

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