Rare ginsenoside Ia synthesized from F1 by cloning and overexpression of the UDP-glycosyltransferase gene from Bacillus subtilis: synthesis, characterization, and in vitro melanogenesis inhibition activity in BL6B16 cells

Rare ginsenoside Ia synthesized from F1 by cloning and overexpression of the UDP-glycosyltransferase gene from Bacillus subtilis: synthesis, characterization, and in vitro melanogenesis inhibition activity in BL6B16 cells

Background: Ginsenoside F1 has been described to possess skin-whitening effects on humans. We aimed to synthesize a new ginsenoside derivative from F1 and investigate its cytotoxicity and melanogenesis inhibitory activity in B16BL6 cells using recombinant glycosyltransferase enzyme. Glycosylation ha...

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Bibliographic Details
Main Authors: Dan-Dan Wang, Yan Jin, Chao Wang, Yeon-Ju Kim, Zuly Elizabeth Jimenez Perez, Nam In Baek, Ramya Mathiyalagan, Josua Markus, Deok-Chun Yang
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Journal of Ginseng Research
Subjects:
UDP-glycosyltransferase
ginsenoside F1
melanogenesis
ginsenoside Ia
B16BL6 cell line
Online Access:http://www.sciencedirect.com/science/article/pii/S1226845316301464

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http://www.sciencedirect.com/science/article/pii/S1226845316301464

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