EYA2 suppresses the progression of hepatocellular carcinoma via SOCS3-mediated blockade of JAK/STAT signaling

EYA2 suppresses the progression of hepatocellular carcinoma via SOCS3-mediated blockade of JAK/STAT signaling

Abstract Background Somatic mutations are involved in hepatocellular carcinoma (HCC) progression, but the genetic mechanism associated to hepatocarcinogenesis remains poorly understood. We report that Eyes absent homolog 2 (EYA2) suppresses the HCC progression, while EYA2(A510E) mutation identified...

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Bibliographic Details
Main Authors: Ze-Kun Liu, Can Li, Ren-Yu Zhang, Ding Wei, Yu-Kui Shang, Yu-Le Yong, Ling-Min Kong, Nai-Shan Zheng, Ke Liu, Meng Lu, Man Liu, Cai-Xia Hu, Xiao-Zhen Yang, Zhi-Nan Chen, Huijie Bian
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Molecular Cancer
Subjects:
Whole-exome sequencing
Eyes absent homolog 2
Somatic mutation
Tumor suppressor gene
Unfolded protein response
JAK/STAT signaling pathway
Online Access:https://doi.org/10.1186/s12943-021-01377-9

Internet

https://doi.org/10.1186/s12943-021-01377-9

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