A Novel Dermaseptin Isolated from the Skin Secretion of <i>Phyllomedusa tarsius</i> and Its Cationicity-Enhanced Analogue Exhibiting Effective Antimicrobial and Anti-Proliferative Activities

A Novel Dermaseptin Isolated from the Skin Secretion of <i>Phyllomedusa tarsius</i> and Its Cationicity-Enhanced Analogue Exhibiting Effective Antimicrobial and Anti-Proliferative Activities

A novel dermaseptin peptide, dermaseptin-PT9 (DPT9), was isolated and identified from <i>Phyllomedusa tarsius</i> by the combination of molecular cloning and LC-MS analysis. Chemically synthesised DPT9 was broadly effective against the tested microorganisms through the disruption of cell...

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Bibliographic Details
Main Authors: Miaoran Li, Xinping Xi, Chengbang Ma, Xiaoling Chen, Mei Zhou, James F. Burrows, Tianbao Chen, Lei Wang
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Biomolecules
Subjects:
antimicrobial peptide
frog skin secretion
dermaseptin
Online Access:https://www.mdpi.com/2218-273X/9/10/628

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