Mesoscopic Mapping of Ictal Neurovascular Coupling in Awake Behaving Mice Using Optical Spectroscopy and Genetically Encoded Calcium Indicators

Mesoscopic Mapping of Ictal Neurovascular Coupling in Awake Behaving Mice Using Optical Spectroscopy and Genetically Encoded Calcium Indicators

Unambiguously identifying an epileptic focus with high spatial resolution is a challenge, especially when no anatomic abnormality can be detected. Neurovascular coupling (NVC)-based brain mapping techniques are often applied in the clinic despite a poor understanding of ictal NVC mechanisms, derived...

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Bibliographic Details
Main Authors: Fan Yang, Jing Li, Yan Song, Mingrui Zhao, James E. Niemeyer, Peijuan Luo, Dan Li, Weihong Lin, Hongtao Ma, Theodore H. Schwartz
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Neuroscience
Subjects:
neurovascular coupling
awake
ictal event
mesoscopic optical imaging
mice
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.704834/full

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