How Viruses Contribute to the Pathogenesis of Hemophagocytic Lymphohistiocytosis

How Viruses Contribute to the Pathogenesis of Hemophagocytic Lymphohistiocytosis

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening, hyperinflammatory syndrome, characterized by the uncontrolled activation of macrophages and T cells, eliciting key symptoms such as persistent fever, hepatosplenomegaly, pancytopenia, hemophagocytosis, hyperferritinemia, and coagulopath...

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Bibliographic Details
Main Authors: Ellen Brisse, Carine H. Wouters, Graciela Andrei, Patrick Matthys
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Immunology
Subjects:
hemophagocytic lymphohistiocytosis
macrophage activation syndrome
pathogenesis
herpesviruses
DNA viruses
infection
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01102/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01102/full

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