Analgesic Effects of Lipid Raft Disruption by Sphingomyelinase and Myriocin via Transient Receptor Potential Vanilloid 1 and Transient Receptor Potential Ankyrin 1 Ion Channel Modulation

Analgesic Effects of Lipid Raft Disruption by Sphingomyelinase and Myriocin via Transient Receptor Potential Vanilloid 1 and Transient Receptor Potential Ankyrin 1 Ion Channel Modulation

Transient Receptor Potential (TRP) Vanilloid 1 and Ankyrin 1 (TRPV1, TRPA1) cation channels are expressed in nociceptive primary sensory neurons, and integratively regulate nociceptor and inflammatory functions. Lipid rafts are liquid-ordered plasma membrane microdomains rich in cholesterol, sphingo...

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Bibliographic Details
Main Authors: Ádám Horváth, Maja Payrits, Anita Steib, Boglárka Kántás, Tünde Biró-Süt, János Erostyák, Géza Makkai, Éva Sághy, Zsuzsanna Helyes, Éva Szőke
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
lipid raft
myriocin
pain
sensory neuron
sphingomyelinase
transient receptor potential
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.593319/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.593319/full

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