Heating Efficiency of Triple Vortex State Cylindrical Magnetic Nanoparticles
Abstract A well-established method for treating cancerous tumors is magnetic hyperthermia, which uses localized heat generated by the relaxation mechanism of magnetic nanoparticles (MNPs) in a high-frequency alternating magnetic field. In this work, we investigate the heating efficiency of cylindric...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
SpringerOpen
2019-12-01
|
Series: | Nanoscale Research Letters |
Subjects: | |
Online Access: | https://doi.org/10.1186/s11671-019-3169-6 |
id |
doaj-45c41e7c112147029cde1e3a310645f6 |
---|---|
record_format |
Article |
spelling |
doaj-45c41e7c112147029cde1e3a310645f62020-12-20T12:10:36ZengSpringerOpenNanoscale Research Letters1931-75731556-276X2019-12-0114111010.1186/s11671-019-3169-6Heating Efficiency of Triple Vortex State Cylindrical Magnetic NanoparticlesDe Wei Wong0Wei Liang Gan1Yuan Kai Teo2Wen Siang Lew3School of Physical and Mathematical Sciences, Nanyang Technological UniversitySchool of Physical and Mathematical Sciences, Nanyang Technological UniversitySchool of Biological Sciences, Nanyang Technological UniversitySchool of Physical and Mathematical Sciences, Nanyang Technological UniversityAbstract A well-established method for treating cancerous tumors is magnetic hyperthermia, which uses localized heat generated by the relaxation mechanism of magnetic nanoparticles (MNPs) in a high-frequency alternating magnetic field. In this work, we investigate the heating efficiency of cylindrical NiFe MNPs, fabricated by template-assisted pulsed electrodeposition combined with differential chemical etching. The cylindrical geometry of the MNP enables the formation of the triple vortex state, which increases the heat generation efficiency by four times. Using time-dependent calorimetric measurements, the specific absorption rate (SAR) of the MNPs was determined and compared with the numerical calculations from micromagnetic simulations and vibrating sample magnetometer measurements. The magnetization reversal of high aspect ratios MNPs showed higher remanent magnetization and low-field susceptibility leading to higher hysteresis losses, which was reflected in higher experimental and theoretical SAR values. The SAR dependence on magnetic field strength exhibited small SAR values at low magnetic fields and saturates at high magnetic fields, which is correlated to the coercive field of the MNPs and a characteristic feature of ferromagnetic MNPs. The optimization of cylindrical NiFe MNPs will play a pivotal role in producing high heating performance and biocompatible magnetic hyperthermia agents.https://doi.org/10.1186/s11671-019-3169-6Magnetic nanoparticlesMagnetic hyperthermiaSpecific absorption rateHeLa cells |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
De Wei Wong Wei Liang Gan Yuan Kai Teo Wen Siang Lew |
spellingShingle |
De Wei Wong Wei Liang Gan Yuan Kai Teo Wen Siang Lew Heating Efficiency of Triple Vortex State Cylindrical Magnetic Nanoparticles Nanoscale Research Letters Magnetic nanoparticles Magnetic hyperthermia Specific absorption rate HeLa cells |
author_facet |
De Wei Wong Wei Liang Gan Yuan Kai Teo Wen Siang Lew |
author_sort |
De Wei Wong |
title |
Heating Efficiency of Triple Vortex State Cylindrical Magnetic Nanoparticles |
title_short |
Heating Efficiency of Triple Vortex State Cylindrical Magnetic Nanoparticles |
title_full |
Heating Efficiency of Triple Vortex State Cylindrical Magnetic Nanoparticles |
title_fullStr |
Heating Efficiency of Triple Vortex State Cylindrical Magnetic Nanoparticles |
title_full_unstemmed |
Heating Efficiency of Triple Vortex State Cylindrical Magnetic Nanoparticles |
title_sort |
heating efficiency of triple vortex state cylindrical magnetic nanoparticles |
publisher |
SpringerOpen |
series |
Nanoscale Research Letters |
issn |
1931-7573 1556-276X |
publishDate |
2019-12-01 |
description |
Abstract A well-established method for treating cancerous tumors is magnetic hyperthermia, which uses localized heat generated by the relaxation mechanism of magnetic nanoparticles (MNPs) in a high-frequency alternating magnetic field. In this work, we investigate the heating efficiency of cylindrical NiFe MNPs, fabricated by template-assisted pulsed electrodeposition combined with differential chemical etching. The cylindrical geometry of the MNP enables the formation of the triple vortex state, which increases the heat generation efficiency by four times. Using time-dependent calorimetric measurements, the specific absorption rate (SAR) of the MNPs was determined and compared with the numerical calculations from micromagnetic simulations and vibrating sample magnetometer measurements. The magnetization reversal of high aspect ratios MNPs showed higher remanent magnetization and low-field susceptibility leading to higher hysteresis losses, which was reflected in higher experimental and theoretical SAR values. The SAR dependence on magnetic field strength exhibited small SAR values at low magnetic fields and saturates at high magnetic fields, which is correlated to the coercive field of the MNPs and a characteristic feature of ferromagnetic MNPs. The optimization of cylindrical NiFe MNPs will play a pivotal role in producing high heating performance and biocompatible magnetic hyperthermia agents. |
topic |
Magnetic nanoparticles Magnetic hyperthermia Specific absorption rate HeLa cells |
url |
https://doi.org/10.1186/s11671-019-3169-6 |
work_keys_str_mv |
AT deweiwong heatingefficiencyoftriplevortexstatecylindricalmagneticnanoparticles AT weilianggan heatingefficiencyoftriplevortexstatecylindricalmagneticnanoparticles AT yuankaiteo heatingefficiencyoftriplevortexstatecylindricalmagneticnanoparticles AT wensianglew heatingefficiencyoftriplevortexstatecylindricalmagneticnanoparticles |
_version_ |
1724376924658073600 |