Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction
The correct folding of proteins often requires the intervention molecular chaperones, which can occur co-translationally. Here the authors identify elements of yeast Ssb (Hsp70) that mediate ribosomal binding, and suggest a mechanism that directs efficient interaction of Ssb with the nascent chain.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2016-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13695 |
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doaj-45bf1ec4fc9046fa86502a2fa61438d3 |
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Article |
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doaj-45bf1ec4fc9046fa86502a2fa61438d32021-05-11T11:09:35ZengNature Publishing GroupNature Communications2041-17232016-12-017111310.1038/ncomms13695Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interactionMarie A. Hanebuth0Roman Kityk1Sandra J. Fries2Alok Jain3Allison Kriel4Veronique Albanese5Tancred Frickey6Christine Peter7Matthias P. Mayer8Judith Frydman9Elke Deuerling10Department of Biology, Molecular Microbiology, University of KonstanzCenter for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH AllianceDepartment of Biology, Molecular Microbiology, University of KonstanzDepartment of Chemistry, University of KonstanzDepartment of Biology, Stanford UniversityDepartment of Biology, Stanford UniversityDepartment of Biology, Applied Bioinformatics, University of KonstanzDepartment of Chemistry, University of KonstanzCenter for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH AllianceDepartment of Biology, Stanford UniversityDepartment of Biology, Molecular Microbiology, University of KonstanzThe correct folding of proteins often requires the intervention molecular chaperones, which can occur co-translationally. Here the authors identify elements of yeast Ssb (Hsp70) that mediate ribosomal binding, and suggest a mechanism that directs efficient interaction of Ssb with the nascent chain.https://doi.org/10.1038/ncomms13695 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Marie A. Hanebuth Roman Kityk Sandra J. Fries Alok Jain Allison Kriel Veronique Albanese Tancred Frickey Christine Peter Matthias P. Mayer Judith Frydman Elke Deuerling |
| spellingShingle |
Marie A. Hanebuth Roman Kityk Sandra J. Fries Alok Jain Allison Kriel Veronique Albanese Tancred Frickey Christine Peter Matthias P. Mayer Judith Frydman Elke Deuerling Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction Nature Communications |
| author_facet |
Marie A. Hanebuth Roman Kityk Sandra J. Fries Alok Jain Allison Kriel Veronique Albanese Tancred Frickey Christine Peter Matthias P. Mayer Judith Frydman Elke Deuerling |
| author_sort |
Marie A. Hanebuth |
| title |
Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction |
| title_short |
Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction |
| title_full |
Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction |
| title_fullStr |
Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction |
| title_full_unstemmed |
Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction |
| title_sort |
multivalent contacts of the hsp70 ssb contribute to its architecture on ribosomes and nascent chain interaction |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-12-01 |
| description |
The correct folding of proteins often requires the intervention molecular chaperones, which can occur co-translationally. Here the authors identify elements of yeast Ssb (Hsp70) that mediate ribosomal binding, and suggest a mechanism that directs efficient interaction of Ssb with the nascent chain. |
| url |
https://doi.org/10.1038/ncomms13695 |
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