An Intron 7 Polymorphism in APP Affects the Age of Onset of Dementia in Down Syndrome

An Intron 7 Polymorphism in APP Affects the Age of Onset of Dementia in Down Syndrome

People with Down syndrome (DS) develop Alzheimer's disease (AD) with an early age of onset. A tetranucleotide repeat, attt5−8, in intron 7 of the amyloid precursor protein has been associated with the age of onset of AD in DS in a preliminary study. The authors examine the impact of this poly...

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Bibliographic Details
Main Authors: Emma L. Jones, Clive G. Ballard, Vee P. Prasher, Matthew Arno, Stephen Tyrer, Brian Moore, Maria Luisa Hanney
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:International Journal of Alzheimer's Disease
Online Access:http://dx.doi.org/10.4061/2011/929102

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