An Ultrasensitive Calcium Reporter System via CRISPR-Cas9-Mediated Genome Editing in Human Pluripotent Stem Cells

An Ultrasensitive Calcium Reporter System via CRISPR-Cas9-Mediated Genome Editing in Human Pluripotent Stem Cells

Summary: Genetically encoded calcium indicator (GCaMP) proteins have been reported for imaging cardiac cell activity based on intracellular calcium transients. To bring human pluripotent stem cell (hPSC)-derived cardiomyocytes (CMs) to the clinic, it is critical to evaluate the functionality of CMs....

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Bibliographic Details
Main Authors:	Yuqian Jiang, Yuxiao Zhou, Xiaoping Bao, Chuanxin Chen, Lauren N. Randolph, Jing Du, Xiaojun Lance Lian
Format:	Article
Language:	English
Published:	Elsevier 2018-11-01
Series:	iScience
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004218301664

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