Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex

The tripartite multidrug efflux system MexAB-OprM is a major actor in Pseudomonas aeruginosa antibiotic resistance by exporting a large variety of antimicrobial compounds. Here authors present cryo-EM structures of MexB at various stages of the assembly process and provide evidence that MexB activat...

Full description

Bibliographic Details
Main Authors:	Marie Glavier, Dhenesh Puvanendran, Dimitri Salvador, Marion Decossas, Gilles Phan, Cyril Garnier, Elisa Frezza, Quentin Cece, Guy Schoehn, Martin Picard, Jean-Christophe Taveau, Laetitia Daury, Isabelle Broutin, Olivier Lambert
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-18770-5

id	doaj-45b848677d664bb2a4cbada3e29d4ee0
record_format	Article
spelling	doaj-45b848677d664bb2a4cbada3e29d4ee02021-10-03T11:51:57ZengNature Publishing GroupNature Communications2041-17232020-10-0111111110.1038/s41467-020-18770-5Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complexMarie Glavier0Dhenesh Puvanendran1Dimitri Salvador2Marion Decossas3Gilles Phan4Cyril Garnier5Elisa Frezza6Quentin Cece7Guy Schoehn8Martin Picard9Jean-Christophe Taveau10Laetitia Daury11Isabelle Broutin12Olivier Lambert13University of BordeauxLaboratoire de Biologie Physico-Chimique des Protéines Membranaires, Université de ParisUniversity of BordeauxUniversity of BordeauxLaboratoire CiTCoM, Université de Paris, CNRSLaboratoire CiTCoM, Université de Paris, CNRSLaboratoire CiTCoM, Université de Paris, CNRSLaboratoire de Biologie Physico-Chimique des Protéines Membranaires, Université de ParisUniversité Grenoble Alpes, CNRS, CEA, Institute for Structural Biology (IBS)Laboratoire de Biologie Physico-Chimique des Protéines Membranaires, Université de ParisUniversity of BordeauxUniversity of BordeauxLaboratoire CiTCoM, Université de Paris, CNRSUniversity of BordeauxThe tripartite multidrug efflux system MexAB-OprM is a major actor in Pseudomonas aeruginosa antibiotic resistance by exporting a large variety of antimicrobial compounds. Here authors present cryo-EM structures of MexB at various stages of the assembly process and provide evidence that MexB activation is mediated by OprM and MexA.https://doi.org/10.1038/s41467-020-18770-5
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Marie Glavier Dhenesh Puvanendran Dimitri Salvador Marion Decossas Gilles Phan Cyril Garnier Elisa Frezza Quentin Cece Guy Schoehn Martin Picard Jean-Christophe Taveau Laetitia Daury Isabelle Broutin Olivier Lambert
spellingShingle	Marie Glavier Dhenesh Puvanendran Dimitri Salvador Marion Decossas Gilles Phan Cyril Garnier Elisa Frezza Quentin Cece Guy Schoehn Martin Picard Jean-Christophe Taveau Laetitia Daury Isabelle Broutin Olivier Lambert Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex Nature Communications
author_facet	Marie Glavier Dhenesh Puvanendran Dimitri Salvador Marion Decossas Gilles Phan Cyril Garnier Elisa Frezza Quentin Cece Guy Schoehn Martin Picard Jean-Christophe Taveau Laetitia Daury Isabelle Broutin Olivier Lambert
author_sort	Marie Glavier
title	Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex
title_short	Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex
title_full	Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex
title_fullStr	Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex
title_full_unstemmed	Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex
title_sort	antibiotic export by mexb multidrug efflux transporter is allosterically controlled by a mexa-oprm chaperone-like complex
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-10-01
description	The tripartite multidrug efflux system MexAB-OprM is a major actor in Pseudomonas aeruginosa antibiotic resistance by exporting a large variety of antimicrobial compounds. Here authors present cryo-EM structures of MexB at various stages of the assembly process and provide evidence that MexB activation is mediated by OprM and MexA.
url	https://doi.org/10.1038/s41467-020-18770-5
work_keys_str_mv	AT marieglavier antibioticexportbymexbmultidrugeffluxtransporterisallostericallycontrolledbyamexaoprmchaperonelikecomplex AT dheneshpuvanendran antibioticexportbymexbmultidrugeffluxtransporterisallostericallycontrolledbyamexaoprmchaperonelikecomplex AT dimitrisalvador antibioticexportbymexbmultidrugeffluxtransporterisallostericallycontrolledbyamexaoprmchaperonelikecomplex AT mariondecossas antibioticexportbymexbmultidrugeffluxtransporterisallostericallycontrolledbyamexaoprmchaperonelikecomplex AT gillesphan antibioticexportbymexbmultidrugeffluxtransporterisallostericallycontrolledbyamexaoprmchaperonelikecomplex AT cyrilgarnier antibioticexportbymexbmultidrugeffluxtransporterisallostericallycontrolledbyamexaoprmchaperonelikecomplex AT elisafrezza antibioticexportbymexbmultidrugeffluxtransporterisallostericallycontrolledbyamexaoprmchaperonelikecomplex AT quentincece antibioticexportbymexbmultidrugeffluxtransporterisallostericallycontrolledbyamexaoprmchaperonelikecomplex AT guyschoehn antibioticexportbymexbmultidrugeffluxtransporterisallostericallycontrolledbyamexaoprmchaperonelikecomplex AT martinpicard antibioticexportbymexbmultidrugeffluxtransporterisallostericallycontrolledbyamexaoprmchaperonelikecomplex AT jeanchristophetaveau antibioticexportbymexbmultidrugeffluxtransporterisallostericallycontrolledbyamexaoprmchaperonelikecomplex AT laetitiadaury antibioticexportbymexbmultidrugeffluxtransporterisallostericallycontrolledbyamexaoprmchaperonelikecomplex AT isabellebroutin antibioticexportbymexbmultidrugeffluxtransporterisallostericallycontrolledbyamexaoprmchaperonelikecomplex AT olivierlambert antibioticexportbymexbmultidrugeffluxtransporterisallostericallycontrolledbyamexaoprmchaperonelikecomplex
_version_	1716845112407883776

Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex

Similar Items