Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex
The tripartite multidrug efflux system MexAB-OprM is a major actor in Pseudomonas aeruginosa antibiotic resistance by exporting a large variety of antimicrobial compounds. Here authors present cryo-EM structures of MexB at various stages of the assembly process and provide evidence that MexB activat...
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Bibliographic Details
| Main Authors: |
Marie Glavier,
Dhenesh Puvanendran,
Dimitri Salvador,
Marion Decossas,
Gilles Phan,
Cyril Garnier,
Elisa Frezza,
Quentin Cece,
Guy Schoehn,
Martin Picard,
Jean-Christophe Taveau,
Laetitia Daury,
Isabelle Broutin,
Olivier Lambert |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2020-10-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-18770-5
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