Effect of lornoxicam on inflammatory markers in patients with non-ST-segment elevation acute coronary syndrome

• Main Authors: Nikita Valer'evich Lomakin, Aleksey Kirillovich Gruzdev, N V Lomakin, A K Gruzdev
• Format: Article
• Language: Russian
• Published: "Consilium Medicum" Publishing house 2010-12-01
• Series: Терапевтический архив
• Subjects: acute coronary syndrome; nonsteroidal anti-inflammatory drug; inflammatory markers
• Online Access: https://ter-arkhiv.ru/0040-3660/article/view/30737
• ISSN: 0040-3660; 2309-5342

Aim. To evaluate the clinical efficacy, safety, and effects of the nonsteroidal anti-inflammatory drug lornoxicam on inflammatory markers in non-ST-segment elevation acute coronary syndrome (NSTEACS). Subjects and methods. Eighty-five patients with NSTESCS were enrolled in a prospective randomized study. They were divided into 2 groups: 1) patients received lornoxicam (8 or 12 mg/daily) for 15 days in addition to standard treatment and 2) controls. Cardiovascular outcomes and the levels of C-reactive protein (CRP), IL-6, and IL-10 were determined. Results. The lornoxicam group exhibited a significant reduction in CRP and a decrease in IL-6. There was also a significant increase in IL-10 levels in this group. A 6-month follow-up indicated a significant reduction in the number of cardiovascular events (nonfatal myocardial infarction, unstable angina, coronary death). Conclusion. Lornoxicam reduces the risk of poor cardiovascular outcomes in patients with NSTEACS and the levels of inflammatory markers.