Microchip screening platform for single cell assessment of NK cell cytotoxicity

Microchip screening platform for single cell assessment of NK cell cytotoxicity

Here we report a screening platform for assessment of the cytotoxic potential of individual natural killer (NK) cells within larger populations. Human primary NK cells were distributed across a silicon-glass microchip containing 32 400 individual microwells loaded with target cells. Through fluoresc...

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Bibliographic Details
Main Authors: Karolin eGuldevall, Ludwig eBrandt, Elin eForslund, Karl eOlofsson, Thomas Wilhelm Frisk, Per Erik Olofsson, Karin eGustafsson, Bruno eVanherberghen, Otto eManneberg, Hjalmar eBrismar, Klas eKärre, Michael eUhlin, Björn eÖnfelt
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-04-01
Series:Frontiers in Immunology
Subjects:
Microscopy, Fluorescence
NK cells
screening
Cytotoxicity
immune synapse
single cell analysis
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00119/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00119/full

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