Evaluation of Tegaran Formula ZhenHua cytotoxicity against human cancer cell lines.

Evaluation of Tegaran Formula ZhenHua cytotoxicity against human cancer cell lines.

The aim of this study is to evaluate the potential health effects of Tegaran Formula ZhenHua, a nutritional supplement used mainly by cancer patients. Its active ingredients and cytotoxicity was assessed with analytical methods and viability assays, respectively. The analytical methods consisted of...

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Main Authors: Panagiotis Parsonidis, Ioanna Vlachou, Alexandra Mamagkaki, Ioannis Bouris, Vasiliki Daikopoulou, Ioannis Papasotiriou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0240969
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spelling doaj-45a2e7063077436b999c6e1c4425ccd82021-03-04T11:09:31ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-011510e024096910.1371/journal.pone.0240969Evaluation of Tegaran Formula ZhenHua cytotoxicity against human cancer cell lines.Panagiotis ParsonidisIoanna VlachouAlexandra MamagkakiIoannis BourisVasiliki DaikopoulouIoannis PapasotiriouThe aim of this study is to evaluate the potential health effects of Tegaran Formula ZhenHua, a nutritional supplement used mainly by cancer patients. Its active ingredients and cytotoxicity was assessed with analytical methods and viability assays, respectively. The analytical methods consisted of dissolution, disintegration, HPLC, LC/MS, GC/MS and NMR. Cytotoxicity was assessed by MTT, SRB, CVE colorimetric viability assays in 0, 24, 48 and 72h time points. The results indicate that Tegaran Formula ZhenHua supplement did not present any cytotoxic effects due to issues related to the capsules' solubility, distribution and identification of the active ingredient.https://doi.org/10.1371/journal.pone.0240969
collection DOAJ
language English
format Article
sources DOAJ
author Panagiotis Parsonidis
Ioanna Vlachou
Alexandra Mamagkaki
Ioannis Bouris
Vasiliki Daikopoulou
Ioannis Papasotiriou
spellingShingle Panagiotis Parsonidis
Ioanna Vlachou
Alexandra Mamagkaki
Ioannis Bouris
Vasiliki Daikopoulou
Ioannis Papasotiriou
Evaluation of Tegaran Formula ZhenHua cytotoxicity against human cancer cell lines.
PLoS ONE
author_facet Panagiotis Parsonidis
Ioanna Vlachou
Alexandra Mamagkaki
Ioannis Bouris
Vasiliki Daikopoulou
Ioannis Papasotiriou
author_sort Panagiotis Parsonidis
title Evaluation of Tegaran Formula ZhenHua cytotoxicity against human cancer cell lines.
title_short Evaluation of Tegaran Formula ZhenHua cytotoxicity against human cancer cell lines.
title_full Evaluation of Tegaran Formula ZhenHua cytotoxicity against human cancer cell lines.
title_fullStr Evaluation of Tegaran Formula ZhenHua cytotoxicity against human cancer cell lines.
title_full_unstemmed Evaluation of Tegaran Formula ZhenHua cytotoxicity against human cancer cell lines.
title_sort evaluation of tegaran formula zhenhua cytotoxicity against human cancer cell lines.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2020-01-01
description The aim of this study is to evaluate the potential health effects of Tegaran Formula ZhenHua, a nutritional supplement used mainly by cancer patients. Its active ingredients and cytotoxicity was assessed with analytical methods and viability assays, respectively. The analytical methods consisted of dissolution, disintegration, HPLC, LC/MS, GC/MS and NMR. Cytotoxicity was assessed by MTT, SRB, CVE colorimetric viability assays in 0, 24, 48 and 72h time points. The results indicate that Tegaran Formula ZhenHua supplement did not present any cytotoxic effects due to issues related to the capsules' solubility, distribution and identification of the active ingredient.
url https://doi.org/10.1371/journal.pone.0240969
work_keys_str_mv AT panagiotisparsonidis evaluationoftegaranformulazhenhuacytotoxicityagainsthumancancercelllines
AT ioannavlachou evaluationoftegaranformulazhenhuacytotoxicityagainsthumancancercelllines
AT alexandramamagkaki evaluationoftegaranformulazhenhuacytotoxicityagainsthumancancercelllines
AT ioannisbouris evaluationoftegaranformulazhenhuacytotoxicityagainsthumancancercelllines
AT vasilikidaikopoulou evaluationoftegaranformulazhenhuacytotoxicityagainsthumancancercelllines
AT ioannispapasotiriou evaluationoftegaranformulazhenhuacytotoxicityagainsthumancancercelllines
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