12/15-Lipoxygenase-dependent ROS production is required for diet-induced endothelial barrier dysfunction

12/15-Lipoxygenase-dependent ROS production is required for diet-induced endothelial barrier dysfunction

To understand the mechanisms of 15(S)-HETE-induced endothelial cell (EC) barrier dysfunction, we examined the role of xanthine oxidase (XO). 15(S)-HETE induced junction adhesion molecule A (JamA) phosphorylation on Y164, Y218, and Y280 involving XO-mediated reactive oxygen species production and Src...

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Bibliographic Details
Main Authors: Rima Chattopadhyay, Alexander Tinnikov, Elena Dyukova, Nikhlesh K. Singh, Sivareddy Kotla, James A. Mobley, Gadiparthi N. Rao
Format: Article
Language:English
Published: Elsevier 2015-03-01
Series:Journal of Lipid Research
Subjects:
xanthine oxidase
tight junction
15(S)-hydroxyeicosatetraenoic acid
15-lipoxygenase 1
reactive oxygen species
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520355851

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http://www.sciencedirect.com/science/article/pii/S0022227520355851

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